Vitamin B12 - Methylcobalamin (elemental) - 2.5 mcg
In the form of Vitamin B12 Methylcobalamin - 0.0025 mg
Vitamin B deficiencies are common, so a safe supplementation is justified.
For all B vitamins, it is recommended to take a B complex instead of individual B vitamins. These work in synergy with each other and a complex ensures that the underlying relationships are in balance.
Vitamin B12 contains cobalt and is to a limited extent produced by intestinal microorganisms. It is present in animal food. Vegetarians and vegans often develop a vitamin B12 deficiency and can benefit from supplementation. Vitamin B12 plays a role in growth, cell production, hematopoiesis (production of blood cells) and is essential to convert homocysteine into methionine and for the conversion of methyl malonate to succinate. If too much homocysteine remains in the bloodstream, it can be harmful to the vessel wall.
Vitamin B12 is often monitored via biomarkers and deficiencies are frequent (25% of the population). There is scientific discussion as to whether the reference values used by the labs are sufficient. In clinical practice we see, among other things, fatigue complaints improving under substitution.
Deficiencies are often the result of the absence of the 'intrinsic factor'. This is a substance produced by the stomach wall that is required for absorption at the level of the intestine. A second common cause is at the level of the intestine itself: Leaking gut or non-optimally functioning intestinal cells do not absorb vitamin B12 properly.
Even if a balanced diet provides sufficient amounts of B12, supplementation is still justified, certainly to restore the balance with folic acid intake. Bodhi therefore contains 100% of the RI.
Sources(1) HSDB: Cyanocobalamine. (n.d.). Retrieved from https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+68-19-9